The Inflammatory Genetics of Autism

By: David Shifrin, PhD Life Science Consultant and Freelance Writer Discussions about autism – its etiology, its diagnosis, its prevalence now and historically – are seemingly endless. This isn’t surprising. Between the societal impact of autism spectrum disorders (ASD, not that this audience needs the abbreviation defined), the apparent increase in cases, and uncertainty as… Read More The Inflammatory Genetics of Autism

New Guidance for Expanded Carrier Screening

By: David Shifrin, PhD Life Science Consultant and Freelance Writer Expanded carrier screening came about in large part as a result of high-throughput and whole genome sequencing technology. Current medical best practices recommend screening for a specific set of potential inherited genetic conditions (i.e. condition-directed screening). However, as is the case any time high-throughput technology… Read More New Guidance for Expanded Carrier Screening

Tumor Profiling, Part 4: Commercialized molecular tumor profiling

By: David Shifrin, PhD Life Science Consultant and Freelance Writer A number of companies are now offering molecular tumor profiling, some of which are designed to help guide therapeutic intervention. Caris Life Sciences profiles samples with a number of different molecular approaches through their Molecular Intelligence services. This profiling can be tailored by the requesting… Read More Tumor Profiling, Part 4: Commercialized molecular tumor profiling

Tumor Profiling, Part 3: Going off-label

By: David Shifrin, PhD Life Science Consultant and Freelance Writer Limitations to molecular profiling techniques are well known, and scientists are working hard to fill in the gaps. Simultaneously, another issue is beginning to change how the community looks at tumor profiling and treatment. While off-label use is not necessarily a direct result of limitations… Read More Tumor Profiling, Part 3: Going off-label

Tumor Profiling, Part 2: Limitations

By: David Shifrin, PhD Life Science Consultant and Freelance Writer Following on the previous post introducing molecular profiling, we will now spend more time examining some of the limitations that have arisen from these techniques. Limitations of Molecular profiling Even from a prognostic standpoint, tumor profiling tests have their limitations. The molecular signature of any… Read More Tumor Profiling, Part 2: Limitations